Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease
- A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging, cancer, and other disorders.2 As an outstanding achievement, the authors identified DSCC1 (DNA Replication And Sister Chromatid Cohesion 1) as a critical gene protecting against early developmental defects, genomic instability, reduced proliferative capacity, cohesinopathy-related phenotypes, and tumor development in vivo.
| Author: | Jörg Fahrer |
|---|---|
| URN: | urn:nbn:de:hbz:386-kluedo-96571 |
| ISSN: | 2059-3635 |
| Parent Title (English): | Signal Transduction and Targeted Therapy |
| Publisher: | Springer |
| Document Type: | Article |
| Language of publication: | English |
| Date of Publication (online): | 2024/06/14 |
| Year of first Publication: | 2024 |
| Publishing Institution: | Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau |
| Date of the Publication (Server): | 2026/02/26 |
| Issue: | 9 / 1 |
| Page Number: | 3 |
| Source: | 10.1038/s41392-024-01869-2 |
| Faculties / Organisational entities: | Kaiserslautern - Fachbereich Chemie |
| DDC-Cassification: | 5 Naturwissenschaften und Mathematik / 540 Chemie |
| Collections: | Open-Access-Publikationsfonds |
| Licence (German): | Lizenz nach Originalpublikation |