Fe65: A Scaffolding Protein of Actin Regulators

  • The scaffolding protein family Fe65, composed of Fe65, Fe65L1, and Fe65L2, was identified as an interaction partner of the amyloid precursor protein (APP), which plays a key function in Alzheimer’s disease. All three Fe65 family members possess three highly conserved interaction domains, forming complexes with diverse binding partners that can be assigned to different cellular functions, such as transactivation of genes in the nucleus, modulation of calcium homeostasis and lipid metabolism, and regulation of the actin cytoskeleton. In this article, we rule out putative new intracellular signaling mechanisms of the APP-interacting protein Fe65 in the regulation of actin cytoskeleton dynamics in the context of various neuronal functions, such as cell migration, neurite outgrowth, and synaptic plasticity.
Author:Vanessa Augustin, Stefan Kins
Parent Title (English):Cells, Special Issue: Molecular Mechanisms of Neuronal Actin Cytoskeleton Dynamics
Document Type:Article
Language of publication:English
Publication Date:2021/06/25
Year of Publication:2021
Publishing Institute:Technische Universität Kaiserslautern
Date of the Publication (Server):2022/01/24
Tag:Arf6; Arp2/3; DOCK; ELMO; Mena; Rac; Tip60; cortactin; neurite outgrowth; structural synaptic plasticity
Issue:2021, 10(7), 1599
Faculties / Organisational entities:Kaiserslautern - Fachbereich Biologie
DDC-Cassification:5 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie
Licence (German):Zweitveröffentlichung