Synthetic Receptors Based on Abiotic Cyclo(pseudo)peptides

  • Work on the use of cyclic peptides or pseudopeptides as synthetic receptors started even before the field of supramolecular chemistry was firmly established. Research initially focused on the development of synthetic ionophores and involved the use of macrocycles with a repeating sequence of subunits along the ring to facilitate the correlation between structure, conformation, and binding properties. Later, nonnatural amino acids as building blocks were also considered. With growing research in this area, cyclopeptides and related macrocycles developed into an important and structurally diverse receptor family. This review provides an overview of these developments, starting from the early years. The presented systems are classified according to characteristic structural elements present along the ring. Wherever possible, structural aspects are correlated with binding properties to illustrate how natural or nonnatural amino acids affect binding properties.

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Author:Stefan KubikORCiD
Parent Title (English):Molecules
Place of publication:Basel, Schweiz
Document Type:Article
Language of publication:English
Publication Date:2022/04/28
Year of Publication:2022
Publishing Institute:Technische Universität Kaiserslautern
Date of the Publication (Server):2022/08/22
Tag:amino acids; cyclic pseudopeptides; cyclopeptides; molecular recognition; supramolecular chemistry; synthetic receptors
Issue:2022, 27(9), 2821
Number of page:35
Source: 10.3390/molecules27092821
Faculties / Organisational entities:Kaiserslautern - Fachbereich Chemie
DDC-Cassification:5 Naturwissenschaften und Mathematik / 540 Chemie
Licence (German):Zweitveröffentlichung