Influence of Bilberry Extract on Neuronal Cell Toxicity

  • Increased intake of dietary antioxidants such as anthocyanins, which are enriched in colourful fruits, is a promising alternative to reduce the risk of degenerative diseases such as Alzheimer’s Disease (AD). Since Amyloid β (Aβ) is one of the key components contributing to AD pathology, probably by reactive oxygen species (ROS) induction, this study investigated the preventive effect of anthocyanin-rich bilberry extract (BE) and its anthocyanin fraction (ACN) on ROS generation and cell toxicity. The results showed a significant and concentration-dependent decrease in neuroblastoma cell (SH-SY5Y) viability by BE or ACN, whereas no cell toxicity was observed in HeLa cells. Incubation with BE and ACN for 24 h diminished the generation of induced ROS levels in SH-SY5Y and HeLa cells. In addition, low concentrations of BE (1–5 µg/mL) showed protective effects against Aβ-induced cytotoxicity in SH-SY5Y cells. In conclusion, our results suggest antioxidant and protective effects of BE and ACN, which could potentially be used to delay the course of neurodegenerative diseases such as AD. Further studies are needed to clarify the high potential of anthocyanins and their in vivo metabolites on neuronal function.

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Author:Svenja König, Tamara Bakuradze, Sandy Jesser, Harshitha Ashoka Sreeja, Max J. Carlsson, Jörg Fahrer, Stefan Kins, Elke RichlingORCiD
URN:urn:nbn:de:hbz:386-kluedo-86463
ISSN:2079-7737
Parent Title (English):Biology
Publisher:MDPI
Document Type:Article
Language of publication:English
Date of Publication (online):2024/05/25
Year of first Publication:2024
Publishing Institution:Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
Date of the Publication (Server):2025/01/23
Issue:2024, 13(6), 376
Page Number:10
Source:10.3390/biology13060376
Faculties / Organisational entities:Kaiserslautern - Fachbereich Chemie
DDC-Cassification:5 Naturwissenschaften und Mathematik / 540 Chemie
Collections:Open-Access-Publikationsfonds
Licence (German):Zweitveröffentlichung