Oxyenamides as Versatile Building Blocks for a Highly Stereoselective One-Pot Synthesis of the 1,3-Diamino-2-ol-Scaffold Containing Three Continuous Stereocenters
- A highly diastereoselective one-pot synthesis of the 1,3-diamino-2-alcohol unit bearing three continuous stereocenters is described. This method utilizes 2-oxyenamides as a novel type of building block for the rapid assembly of the 1,3-diamine scaffold containing an additional stereogenic oxygen functionality at the C2 position. A stereoselective preparation of the required (Z)-oxyenamides is reported as well.
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| Author: | Sara-Cathrin Krieg, Jennifer Grimmer, Philipp KramerORCiD, Michael BolteORCiD, Harald Kelm, Georg ManolikakesORCiD |
|---|---|
| URN: | urn:nbn:de:hbz:386-kluedo-80434 |
| DOI: | https://doi.org/10.1002/anie.202109752 |
| ISSN: | 1521-3773 |
| Parent Title (English): | Angewandte Chemie International Edition |
| Publisher: | Wiley |
| Document Type: | Article |
| Language of publication: | English |
| Date of Publication (online): | 2024/04/16 |
| Year of first Publication: | 2021 |
| Publishing Institution: | Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau |
| Date of the Publication (Server): | 2024/04/16 |
| Issue: | 60/44 |
| Page Number: | 5 |
| First Page: | 23667 |
| Last Page: | 23671 |
| Source: | https://onlinelibrary.wiley.com/doi/10.1002/anie.202109752 |
| Faculties / Organisational entities: | Kaiserslautern - Fachbereich Chemie |
| DDC-Cassification: | 5 Naturwissenschaften und Mathematik / 540 Chemie |
| Collections: | Open-Access-Publikationsfonds |
| Licence (German): | Lizenz nach Originalpublikation |